"Nothingness" is one of the complex philosophical and mystical issues which its meaning can answer one of the most important ontological problems, namely the beginning and end of the world. The reflection of the meanings of nothingness in Islamic mysticism and Buddhism can be considered. Rumi as one of the great Islamic mystics, has used the Nothingness in many meanings. In Buddhist texts, Prajñāpāramitā and Mūlamadhyamakakārikā, which are considered as important educational texts of Buddhism, nothingness and its meaning is one of the main and central issues.
     In this research, a descriptive-analytical method has been attempted Rumichr('39')s view on nothingness in Masnavi with its meanings in these two texts should be examined. It also introduces two important Buddhist texts. The result shows that to consider nothingness the nature of the phenomena of the universe has been raised in Masnavi and these two texts. But to consider that nothingness is the beginning and the end of phenomena, God or absolute Truth and the ultimate goal of the seeker, are meanings that are mentioned with differences in the texts. The root of these differences can be found in the type of knowledge and ontology of Islam and Buddhism. In Islamic mysticism,God is the creator of the existence and the end of the seeker; whereas in Buddhist texts the world comes from nothingness and goes to nothingness And the seekerchr('39')s goal is to get rid of suffering and reach Nirvana.